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| Author | Davidowitz, I.; Parmet, Y.; Frenkel-Toledo, S.; Banina, M.C.; Soroker, N.; Solomon, J.M.; Liebermann, D.G.; Levin, M.F.; Berman, S. | ||||
| Title | Relationship Between Spasticity and Upper-Limb Movement Disorders in Individuals With Subacute Stroke Using Stochastic Spatiotemporal Modeling | Type | Journal Article | ||
| Year | 2019 | Publication | Neurorehabilitation and Neural Repair | Abbreviated Journal | Neurorehabil Neural Repair |
| Volume | 33 | Issue | 2 | Pages | 141-152 |
| Keywords | Gaussian mixture model; Kullback-Liebler divergence; spasticity; stroke; upper-limb kinematics | ||||
| Abstract | BACKGROUND: Spasticity is common in patients with stroke, yet current quantification methods are insufficient for determining the relationship between spasticity and voluntary movement deficits. This is partly a result of the effects of spasticity on spatiotemporal characteristics of movement and the variability of voluntary movement. These can be captured by Gaussian mixture models (GMMs). OBJECTIVES: To determine the influence of spasticity on upper-limb voluntary motion, as assessed by the bidirectional Kullback-Liebler divergence (BKLD) between motion GMMs. METHODS: A total of 16 individuals with subacute stroke and 13 healthy aged-equivalent controls reached to grasp 4 targets (near-center, contralateral, far-center, and ipsilateral). Two-dimensional GMMs (angle and time) were estimated for elbow extension motion. BKLD was computed for each individual and target, within the control group and between the control and stroke groups. Movement time, final elbow angle, average elbow velocity, and velocity smoothness were computed. RESULTS: Between-group BKLDs were much larger than within control-group BKLDs. Between-group BKLDs for the near-center target were lower than those for the far-center and contralateral targets, but similar to that for the ipsilateral target. For those with stroke, the final angle was lower for the near-center target, and the average velocity was higher. Velocity smoothness was lower for the near-center than for the ipsilateral target. Elbow flexor and extensor passive muscle resistance (Modified Ashworth Scale) strongly explained BKLD values. CONCLUSIONS: Results support the view that individuals with poststroke spasticity have a velocity-dependent reduction in active elbow joint range and that BKLD can be used as an objective measure of the effects of spasticity on reaching kinematics. | ||||
| Address | 1 Ben-Gurion University of the Negev, Beer-Sheva, Israel | ||||
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| Language | English | Summary Language | Original Title | ||
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| ISSN | 1545-9683 | ISBN | Medium | ||
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PMID:30744528 | Approved | no | ||
| Call Number | Serial | 93 | |||
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| Author | Dempsey-Jones, H.; Wesselink, D.B.; Friedman, J.; Makin, T.R. | ||||
| Title | Organized Toe Maps in Extreme Foot Users | Type | Journal Article | ||
| Year | 2019 | Publication | Cell Reports | Abbreviated Journal | Cell Reports |
| Volume | 28 | Issue | 11 | Pages | 2748-2756.e4 |
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| Abstract | Although the fine-grained features of topographic maps in the somatosensory cortex can be shaped by everyday experience, it is unknown whether behavior can support the expression of somatotopic maps where they do not typically occur. Unlike the fingers, represented in all primates, individuated toe maps have only been found in non-human primates. Using 1-mm resolution fMRI, we identify organized toe maps in two individuals born without either upper limb who use their feet to substitute missing hand function and even support their profession as foot artists. We demonstrate that the ordering and structure of the artists’ toe representation mimics typical hand representation. We further reveal “hand-like” features of activity patterns, not only in the foot area but also similarly in the missing hand area. We suggest humans may have an innate capacity for forming additional topographic maps that can be expressed with appropriate experience. | ||||
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| Publisher | Elsevier | Place of Publication | Editor | ||
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| ISSN | 2211-1247 | ISBN | Medium | ||
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doi: 10.1016/j.celrep.2019.08.027 | Approved | no | ||
| Call Number | Serial | 99 | |||
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| Author | Ezrati, O.; Friedman, J.; Dar, R. | ||||
| Title | Attenuation of access to internal states in high obsessive-compulsive individuals might increase susceptibility to false feedback: Evidence from a visuo-motor hand-reaching task | Type | Journal Article | ||
| Year | 2019 | Publication | Journal of Behavior Therapy and Experimental Psychiatry | Abbreviated Journal | Journal of Behavior Therapy and Experimental Psychiatry |
| Volume | 65 | Issue | Pages | 101445 | |
| Keywords | Obsessive-compulsive disorder; Movement; Agency; Proprioception; Proxies | ||||
| Abstract | Background and objectives The Seeking Proxies for Internal States (SPIS) model of obsessive-compulsive disorder (OCD) posits that obsessive-compulsive (OC) individuals have attenuated access to their internal states. Hence, they seek and rely on proxies, or discernible substitutes for these internal states. In previous studies, participants with high OC tendencies and OCD patients, compared to controls, showed increased reliance on external proxies and were more influenced by false feedback when judging their internal states. This study is the first to examine the effects of false feedback on performance of hand movements in participants with high and low OC tendencies. Method Thirty-four participants with high OC tendencies and 34 participants with low OC tendencies were asked to perform accurate hand reaches without visual feedback in two separate sessions of a computerized hand-reaching task: once after valid feedback training of their hand location and once with false-rotated feedback. We assessed the accuracy and directional adaptation of participants' reaches. Results As predicted, high OC participants evidenced a larger decrease in their hand positioning accuracy after training with false feedback compared to low OC participants. Limitations The generalization of our findings to OCD requires replication with a clinical sample. Conclusions These results suggest that in addition to self-perceptions, motor performance of OC individuals is prone to be overly influenced by false feedback, possibly due to attenuated access to proprioceptive cues. These findings may be particularly relevant to understanding the distorted sense of agency in OCD. |
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| ISSN | 0005-7916 | ISBN | Medium | ||
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| Notes |
Approved | no | |||
| Call Number | Serial | 95 | |||
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