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	Author	Ezrati, O.; Friedman, J.; Dar, R.
	Title	Attenuation of access to internal states in high obsessive-compulsive individuals might increase susceptibility to false feedback: Evidence from a visuo-motor hand-reaching task			Type	Journal Article
	Year	2019	Publication	Journal of Behavior Therapy and Experimental Psychiatry	Abbreviated Journal	Journal of Behavior Therapy and Experimental Psychiatry
	Volume	65	Issue		Pages	101445
	Keywords	Obsessive-compulsive disorder; Movement; Agency; Proprioception; Proxies
	Abstract	Background and objectives The Seeking Proxies for Internal States (SPIS) model of obsessive-compulsive disorder (OCD) posits that obsessive-compulsive (OC) individuals have attenuated access to their internal states. Hence, they seek and rely on proxies, or discernible substitutes for these internal states. In previous studies, participants with high OC tendencies and OCD patients, compared to controls, showed increased reliance on external proxies and were more influenced by false feedback when judging their internal states. This study is the first to examine the effects of false feedback on performance of hand movements in participants with high and low OC tendencies. Method Thirty-four participants with high OC tendencies and 34 participants with low OC tendencies were asked to perform accurate hand reaches without visual feedback in two separate sessions of a computerized hand-reaching task: once after valid feedback training of their hand location and once with false-rotated feedback. We assessed the accuracy and directional adaptation of participants' reaches. Results As predicted, high OC participants evidenced a larger decrease in their hand positioning accuracy after training with false feedback compared to low OC participants. Limitations The generalization of our findings to OCD requires replication with a clinical sample. Conclusions These results suggest that in addition to self-perceptions, motor performance of OC individuals is prone to be overly influenced by false feedback, possibly due to attenuated access to proprioceptive cues. These findings may be particularly relevant to understanding the distorted sense of agency in OCD.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0005-7916	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number				Serial	95
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	Author	Lerner, O.; Friedman, J.; Frenkel-Toledo, S.
	Title	The effect of high-definition transcranial direct current stimulation intensity on motor performance in healthy adults: a randomized controlled trial			Type	Journal Article
	Year	2021	Publication	Journal of NeuroEngineering and Rehabilitation	Abbreviated Journal	J NeuroEngineering Rehabil
	Volume	18	Issue		Pages	103
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1743-0003	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number				Serial	109
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	Author	Dempsey-Jones, H.; Wesselink, D.B.; Friedman, J.; Makin, T.R.
	Title	Organized Toe Maps in Extreme Foot Users			Type	Journal Article
	Year	2019	Publication	Cell Reports	Abbreviated Journal	Cell Reports
	Volume	28	Issue	11	Pages	2748-2756.e4
	Keywords
	Abstract	Although the fine-grained features of topographic maps in the somatosensory cortex can be shaped by everyday experience, it is unknown whether behavior can support the expression of somatotopic maps where they do not typically occur. Unlike the fingers, represented in all primates, individuated toe maps have only been found in non-human primates. Using 1-mm resolution fMRI, we identify organized toe maps in two individuals born without either upper limb who use their feet to substitute missing hand function and even support their profession as foot artists. We demonstrate that the ordering and structure of the artists’ toe representation mimics typical hand representation. We further reveal “hand-like” features of activity patterns, not only in the foot area but also similarly in the missing hand area. We suggest humans may have an innate capacity for forming additional topographic maps that can be expressed with appropriate experience.
	Address
	Corporate Author				Thesis
	Publisher	Elsevier	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	2211-1247	ISBN		Medium
	Area		Expedition		Conference
	Notes	doi: 10.1016/j.celrep.2019.08.027			Approved	no
	Call Number				Serial	99
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	Author	Grinberg, A.; Strong, A.; Strandberg, J.; Selling, J.; Liebermann, D.G.; Bjorklund, M.; Hager, C.K.
	Title	Electrocortical activity associated with movement-related fear: a methodological exploration of a threat-conditioning paradigm involving destabilising perturbations during quiet standing			Type	Journal Article
	Year	2024	Publication	Experimental Brain Research	Abbreviated Journal	Exp Brain Res
	Volume		Issue		Pages
	Keywords	Cnv; Eeg; Erp; Kinesiophobia; Moving platform; Re-injury anxiety
	Abstract	Musculoskeletal trauma often leads to lasting psychological impacts stemming from concerns of future injuries. Often referred to as kinesiophobia or re-injury anxiety, such concerns have been shown to hinder return to physical activity and are believed to increase the risk for secondary injuries. Screening for re-injury anxiety is currently restricted to subjective questionnaires, which are prone to self-report bias. We introduce a novel approach to objectively identify electrocortical activity associated with the threat of destabilising perturbations. We aimed to explore its feasibility among non-injured persons, with potential future implementation for screening of re-injury anxiety. Twenty-three participants stood blindfolded on a translational balance perturbation platform. Consecutive auditory stimuli were provided as low (neutral stimulus [CS(-)]) or high (conditioned stimulus [CS(+)]) tones. For the main experimental protocol (Protocol I), half of the high tones were followed by a perturbation in one of eight unpredictable directions. A separate validation protocol (Protocol II) requiring voluntary squatting without perturbations was performed with 12 participants. Event-related potentials (ERP) were computed from electroencephalography recordings and significant time-domain components were detected using an interval-wise testing procedure. High-amplitude early contingent negative variation (CNV) waves were significantly greater for CS(+) compared with CS(-) trials in all channels for Protocol I (> 521-800ms), most prominently over frontal and central midline locations (P </= 0.001). For Protocol II, shorter frontal ERP components were observed (541-609ms). Our test paradigm revealed electrocortical activation possibly associated with movement-related fear. Exploring the discriminative validity of the paradigm among individuals with and without self-reported re-injury anxiety is warranted.
	Address	Department of Community Medicine and Rehabilitation, Umea University, Umea, Sweden
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0014-4819	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:38896295			Approved	no
	Call Number				Serial	122
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	Author	Tamir-Ostrover, H.; Hassin-Baer, S.; Fay-Karmon, T.; Friedman, J.
	Title	Quantifying Changes in Dexterity as a Result of Piano Training in People with Parkinson's Disease			Type	Journal Article
	Year	2024	Publication	Sensors (Basel, Switzerland)	Abbreviated Journal	Sensors (Basel)
	Volume	24	Issue	11	Pages
	Keywords	Humans; *Parkinson Disease/physiopathology; Pilot Projects; Male; Aged; Female; Quality of Life; Middle Aged; Motor Skills/physiology; Music; Surveys and Questionnaires; Activities of Daily Living; Fingers/physiology/physiopathology; Parkinson's disease; dexterity; force sensors; music; piano; sonification; training; uncontrolled manifold
	Abstract	People with Parkinson's disease often show deficits in dexterity, which, in turn, can lead to limitations in performing activities of daily life. Previous studies have suggested that training in playing the piano may improve or prevent a decline in dexterity in this population. In this pilot study, we tested three participants on a six-week, custom, piano-based training protocol, and quantified dexterity before and after the intervention using a sensor-enabled version of the nine-hole peg test, the box and block test, a test of finger synergies using unidimensional force sensors, and the Quantitative Digitography test using a digital piano, as well as selected relevant items from the motor parts of the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and the Parkinson's Disease Questionnaire (PDQ-39) quality of life questionnaire. The participants showed improved dexterity following the training program in several of the measures used. This pilot study proposes measures that can track changes in dexterity as a result of practice in people with Parkinson's disease and describes a potential protocol that needs to be tested in a larger cohort.
	Address	Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1424-8220	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:38894110; PMCID:PMC11174779			Approved	no
	Call Number				Serial	124
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