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Author Wilf, M.; Korakin, A.; Bahat, Y.; Koren, O.; Galor, N.; Dagan, O.; Wright, W.G.; Friedman, J.; Plotnik, M. url  doi
openurl 
  Title Using virtual reality-based neurocognitive testing and eye tracking to study naturalistic cognitive-motor performance Type (up) Journal Article
  Year 2024 Publication Neuropsychologia Abbreviated Journal Neuropsychologia  
  Volume 194 Issue Pages 108744  
  Keywords Humans; Aged; *Eye-Tracking Technology; Cognition; Executive Function; *Virtual Reality; Aging; Color trails test; Fall risk; Hand kinematics; Pupil; Virtual reality  
  Abstract Natural human behavior arises from continuous interactions between the cognitive and motor domains. However, assessments of cognitive abilities are typically conducted using pen and paper tests, i.e., in isolation from “real life” cognitive-motor behavior and in artificial contexts. In the current study, we aimed to assess cognitive-motor task performance in a more naturalistic setting while recording multiple motor and eye tracking signals. Specifically, we aimed to (i) delineate the contribution of cognitive and motor components to overall task performance and (ii) probe for a link between cognitive-motor performance and pupil size. To that end, we used a virtual reality (VR) adaptation of a well-established neurocognitive test for executive functions, the 'Color Trails Test' (CTT). The VR-CTT involves performing 3D reaching movements to follow a trail of numbered targets. To tease apart the cognitive and motor components of task performance, we included two additional conditions: a condition where participants only used their eyes to perform the CTT task (using an eye tracking device), incurring reduced motor demands, and a condition where participants manually tracked visually-cued targets without numbers on them, incurring reduced cognitive demands. Our results from a group of 30 older adults (>65) showed that reducing cognitive demands shortened completion times more extensively than reducing motor demands. Conditions with higher cognitive demands had longer target search time, as well as decreased movement execution velocity and head-hand coordination. We found larger pupil sizes in the more cognitively demanding conditions, and an inverse correlation between pupil size and completion times across individuals in all task conditions. Lastly, we found a possible link between VR-CTT performance measures and clinical signatures of participants (fallers versus non-fallers). In summary, performance and pupil parameters were mainly dependent on task cognitive load, while maintaining systematic interindividual differences. We suggest that this paradigm opens the possibility for more detailed profiling of individual cognitive-motor performance capabilities in older adults and other at-risk populations.  
  Address Center of Advanced Technologies in Rehabilitation, Sheba Medical Center, Israel; Department of Physiology and Pharmacology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. Electronic address: Meir.Plotnik@sheba.health.gov.il  
  Corporate Author Thesis  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0028-3932 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:38072162 Approved no  
  Call Number Serial 123  
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Author Tamir-Ostrover, H.; Hassin-Baer, S.; Fay-Karmon, T.; Friedman, J. url  doi
openurl 
  Title Quantifying Changes in Dexterity as a Result of Piano Training in People with Parkinson's Disease Type (up) Journal Article
  Year 2024 Publication Sensors (Basel, Switzerland) Abbreviated Journal Sensors (Basel)  
  Volume 24 Issue 11 Pages  
  Keywords Humans; *Parkinson Disease/physiopathology; Pilot Projects; Male; Aged; Female; Quality of Life; Middle Aged; Motor Skills/physiology; Music; Surveys and Questionnaires; Activities of Daily Living; Fingers/physiology/physiopathology; Parkinson's disease; dexterity; force sensors; music; piano; sonification; training; uncontrolled manifold  
  Abstract People with Parkinson's disease often show deficits in dexterity, which, in turn, can lead to limitations in performing activities of daily life. Previous studies have suggested that training in playing the piano may improve or prevent a decline in dexterity in this population. In this pilot study, we tested three participants on a six-week, custom, piano-based training protocol, and quantified dexterity before and after the intervention using a sensor-enabled version of the nine-hole peg test, the box and block test, a test of finger synergies using unidimensional force sensors, and the Quantitative Digitography test using a digital piano, as well as selected relevant items from the motor parts of the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and the Parkinson's Disease Questionnaire (PDQ-39) quality of life questionnaire. The participants showed improved dexterity following the training program in several of the measures used. This pilot study proposes measures that can track changes in dexterity as a result of practice in people with Parkinson's disease and describes a potential protocol that needs to be tested in a larger cohort.  
  Address Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1424-8220 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:38894110; PMCID:PMC11174779 Approved no  
  Call Number Serial 124  
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Author Lowenthal-Raz, J.; Liebermann, D.G.; Friedman, J.; Soroker, N. url  doi
openurl 
  Title Kinematic descriptors of arm reaching movement are sensitive to hemisphere-specific immediate neuromodulatory effects of transcranial direct current stimulation post stroke Type (up) Journal Article
  Year 2024 Publication Scientific Reports Abbreviated Journal Sci Rep  
  Volume 14 Issue 1 Pages 11971  
  Keywords Humans; *Transcranial Direct Current Stimulation/methods; Male; Female; Middle Aged; *Stroke/physiopathology/therapy; Biomechanical Phenomena; Aged; *Arm/physiopathology; *Movement/physiology; *Stroke Rehabilitation/methods; Single-Blind Method; Cross-Over Studies  
  Abstract Transcranial direct current stimulation (tDCS) exerts beneficial effects on motor recovery after stroke, presumably by enhancement of adaptive neural plasticity. However, patients with extensive damage may experience null or deleterious effects with the predominant application mode of anodal (excitatory) stimulation of the damaged hemisphere. In such cases, excitatory stimulation of the non-damaged hemisphere might be considered. Here we asked whether tDCS exerts a measurable effect on movement quality of the hemiparetic upper limb, following just a single treatment session. Such effect may inform on the hemisphere that should be excited. Using a single-blinded crossover experimental design, stroke patients and healthy control subjects were assessed before and after anodal, cathodal and sham tDCS, each provided during a single session of reaching training (repeated point-to-point hand movement on an electronic tablet). Group comparisons of endpoint kinematics at baseline-number of peaks in the speed profile (NoP; smoothness), hand-path deviations from the straight line (SLD; accuracy) and movement time (MT; speed)-disclosed greater NoP, larger SLD and longer MT in the stroke group. NoP and MT revealed an advantage for anodal compared to sham stimulation of the lesioned hemisphere. NoP and MT improvements under anodal stimulation of the non-lesioned hemisphere correlated positively with the severity of hemiparesis. Damage to specific cortical regions and white-matter tracts was associated with lower kinematic gains from tDCS. The study shows that simple descriptors of movement kinematics of the hemiparetic upper limb are sensitive enough to demonstrate gain from neuromodulation by tDCS, following just a single session of reaching training. Moreover, the results show that tDCS-related gain is affected by the severity of baseline motor impairment, and by lesion topography.  
  Address Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. nachum@soroker.online  
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  Series Volume Series Issue Edition  
  ISSN 2045-2322 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:38796610; PMCID:PMC11127956 Approved no  
  Call Number Serial 125  
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Author Issurin, V.B.; Liebermann, D.G.; Tenenbaum, G. url  doi
openurl 
  Title Effect of vibratory stimulation training on maximal force and flexibility Type (up)
  Year 1994 Publication Journal of Sports Sciences Abbreviated Journal J Sports Sci  
  Volume 12 Issue 6 Pages 561-566  
  Keywords Adult; Humans; Male; Muscle Contraction/physiology; Muscle, Skeletal/*physiology; *Physical Education and Training; Vibration/*therapeutic use  
  Abstract In this study, we investigated a new method of training for maximal strength and flexibility, which included exertion with superimposed vibration (vibratory stimulation, VS) on target muscles. Twenty-eight male athletes were divided into three groups, and trained three times a week for 3 weeks in one of the following conditions: (A) conventional exercises for strength of the arms and VS stretching exercises for the legs; (B) VS strength exercises for the arms and conventional stretching exercises for the legs; (C) irrelevant training (control group). The vibration was applied at 44 Hz while its amplitude was 3 mm. The effect of training was evaluated by means of isotonic maximal force, heel-to-heel length in the two-leg split across, and flex-and-reach test for body flexion. The VS strength training yielded an average increase in isotonic maximal strength of 49.8%, compared with an average gain of 16% with conventional training, while no gain was observed for the control group. The VS flexibility training resulted in an average gain in the legs split of 14.5 cm compared with 4.1 cm for the conventional training and 2 cm for the control groups, respectively. The ANOVA revealed significant pre-post training effects and an interaction between pre-post training and 'treatment' effects (P < 0.001) for the isotonic maximal force and both flexibility tests. It was concluded that superimposed vibrations applied for short periods allow for increased gains in maximal strength and flexibility.  
  Address Ribstein Centre for Research and Sport Medicine Sciences, Wingate Institute, Wingate Post, Israel  
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  Series Volume Series Issue Edition  
  ISSN 0264-0414 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:7853452 Approved no  
  Call Number Serial 56  
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