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Author (up) Davidowitz, I.; Parmet, Y.; Frenkel-Toledo, S.; Banina, M.C.; Soroker, N.; Solomon, J.M.; Liebermann, D.G.; Levin, M.F.; Berman, S. url  doi
openurl 
  Title Relationship Between Spasticity and Upper-Limb Movement Disorders in Individuals With Subacute Stroke Using Stochastic Spatiotemporal Modeling Type Journal Article
  Year 2019 Publication Neurorehabilitation and Neural Repair Abbreviated Journal Neurorehabil Neural Repair  
  Volume 33 Issue 2 Pages 141-152  
  Keywords Gaussian mixture model; Kullback-Liebler divergence; spasticity; stroke; upper-limb kinematics  
  Abstract BACKGROUND: Spasticity is common in patients with stroke, yet current quantification methods are insufficient for determining the relationship between spasticity and voluntary movement deficits. This is partly a result of the effects of spasticity on spatiotemporal characteristics of movement and the variability of voluntary movement. These can be captured by Gaussian mixture models (GMMs). OBJECTIVES: To determine the influence of spasticity on upper-limb voluntary motion, as assessed by the bidirectional Kullback-Liebler divergence (BKLD) between motion GMMs. METHODS: A total of 16 individuals with subacute stroke and 13 healthy aged-equivalent controls reached to grasp 4 targets (near-center, contralateral, far-center, and ipsilateral). Two-dimensional GMMs (angle and time) were estimated for elbow extension motion. BKLD was computed for each individual and target, within the control group and between the control and stroke groups. Movement time, final elbow angle, average elbow velocity, and velocity smoothness were computed. RESULTS: Between-group BKLDs were much larger than within control-group BKLDs. Between-group BKLDs for the near-center target were lower than those for the far-center and contralateral targets, but similar to that for the ipsilateral target. For those with stroke, the final angle was lower for the near-center target, and the average velocity was higher. Velocity smoothness was lower for the near-center than for the ipsilateral target. Elbow flexor and extensor passive muscle resistance (Modified Ashworth Scale) strongly explained BKLD values. CONCLUSIONS: Results support the view that individuals with poststroke spasticity have a velocity-dependent reduction in active elbow joint range and that BKLD can be used as an objective measure of the effects of spasticity on reaching kinematics.  
  Address 1 Ben-Gurion University of the Negev, Beer-Sheva, Israel  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 1545-9683 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30744528 Approved no  
  Call Number Serial 93  
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Author (up) Falk, B.; Eliakim, A.; Dotan, R.; Liebermann, D.G.; Regev, R.; Bar-Or, O. url  openurl
  Title Birth weight and physical ability in 5- to 8-yr-old healthy children born prematurely Type Journal Article
  Year 1997 Publication Medicine and Science in Sports and Exercise Abbreviated Journal Med Sci Sports Exerc  
  Volume 29 Issue 9 Pages 1124-1130  
  Keywords *Birth Weight; Child; Child Development/physiology; Child, Preschool; Female; Follow-Up Studies; Humans; Infant, Newborn; *Infant, Premature; Male; *Motor Skills; *Physical Fitness  
  Abstract Recent advances in perinatal care have resulted in increased survival rates of extremely small and immature newborns. This has resulted in some neurodevelopmental impairment. The purpose of this study was to quantitatively evaluate and compare neuromuscular performance in children born prematurely at various levels of subnormal birth weight (BW). Subjects were 5- to 8-yr-old children born prematurely at different levels of subnormal BW (535-1760 g, N = 22, PM), and age-matched controls born at full term (> 2500 g, N = 15, CON). None of the subjects had any clinically defined neuromuscular disabilities. Body mass (BM) of PM was lower than that of CON (18.3 +/- 2.7 vs 21.7 +/- 3.8 kg) with no difference in height or sum of 4 skinfolds. Peak mechanical power output determined with a 15-s modified Wingate Anaerobic Test and corrected for BM was lower (P = 0.07) in PM than in CON (5.11 +/- 1.07 vs 5.94 +/- 1.00 W.kg-1). This was especially noticeable in children born at extremely low BW (ELBW, < 1000 g, 4.49 +/- 1.04 W.kg-1, P < 0.01). Peak power, determined in a force-plate vertical jump, corrected for BM was lower in PM vs CON (25.5 +/- 5.4 vs 30.8 +/- 5.2 W.kg-1, respectively P = 0.01), especially in the ELBW group (20.0 +/- 5.5 W.kg-1). Similarly, the elapsed time between peak velocity and actual jump take-off was longer in PM than in CON (41.2 +/- 9.4 vs 35.8 +/- 5.8 ms, respectively, P = 0.04). No differences were observed in peak force. The results suggest that performance deficiencies of prematurely-born children may be a result of inferior inter-muscular coordination. The precise neuromotor factors responsible for this should be identified by future research.  
  Address Ribstein Center for Research and Sport Medicine Sciences, Wingate Institute, Netanya, Israel. bfalk@ccsg.tau.ac.il  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0195-9131 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:9309621 Approved no  
  Call Number Serial 64  
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Author (up) Flash, T.; Richardson, M. E.; Handzel, A. A.; Liebermann, D. G. openurl 
  Title Computational Models and Geometric Approaches in Arm Trajectory Control Studies Type Book Chapter
  Year 2003 Publication Progress in Motor Control III: From Basic Science to Applications Abbreviated Journal  
  Volume Issue Pages  
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  Publisher Human Kinetics Place of Publication Champaign, Il Editor M. L. Latash; M. F. Levin  
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  Notes Approved no  
  Call Number Serial 44  
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Author (up) Frenkel-Toledo, S.; Bentin, S.; Perry, A.; Liebermann, D.G.; Soroker, N. url  doi
openurl 
  Title Dynamics of the EEG Power in the Frequency and Spatial Domains During Observation and Execution of Manual Movements Type Journal Article
  Year 2013 Publication Brain Research Abbreviated Journal Brain Res  
  Volume 1509 Issue Pages 43-57  
  Keywords  
  Abstract Mu suppression is the attenuation of EEG power in the alpha frequency range (8-12Hz) while executing or observing a motor action. Whereas typically observed at central scalp sites, there are diverging reports about the extent of the attenuation over the cortical mantle, its exact frequency range and the specificity of this phenomenon. We investigated the modulation of EEG oscillations in frequency-bands from 4 to 12Hz at frontal, central, parietal and occipital sites during the execution of manual movements and during observation of similar actions from allocentric (i.e., facing the actor) and egocentric (i.e., seeing the actor from behind) viewpoints. Suppression was determined relative to observation of a non-biological movement. Action observation elicited greater suppression in the lower (8-10Hz) compared to the higher mu range (10-12Hz), and greater suppression in the entire 4-12Hz range at frontal and central sites compared to parietal and occipital sites. In addition, suppression tended to be greater during observation of a motor action from allocentric compared to egocentric viewpoints. During execution of movement, suppression of the EEG occurred primarily in the higher alpha range and was absent at occipital sites. In the theta range (4-8Hz), the EEG amplitude was suppressed during action observation and execution. The results suggest a functional distinction between modulation of mu and alpha rhythms, and between the higher and lower ranges of the mu rhythms. The activity of the presumed human mirror neuron system seems primarily evident in the lower mu range and in the theta range.  
  Address Sackler Faculty of Medicine, Tel Aviv University, Israel; Department of Neurological Rehabilitation, Loewenstein Hospital, Raanana, Israel. Electronic address: silvi197@bezeqint.net  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0006-8993 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23500633 Approved no  
  Call Number Serial 68  
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Author (up) Frenkel-Toledo, S.; Levin, M.F.; Berman, S.; Liebermann, D.G.; Baniña, M.C.; Solomon, J.M.; Ofir-Geva, S.; Soroker, N. url  doi
openurl 
  Title Shared and distinct voxel-based lesion-symptom mappings for spasticity and impaired movement in the hemiparetic upper limb Type Journal Article
  Year 2022 Publication Scientific Reports Abbreviated Journal Sci Rep  
  Volume 12 Issue 1 Pages  
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  ISSN 2045-2322 ISBN Medium  
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  Notes Approved no  
  Call Number Serial 113  
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