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Author Frenkel-Toledo, S.; Liebermann, D.G.; Bentin, S.; Soroker, N. url  doi
openurl 
  Title Dysfunction of the Human Mirror Neuron System in Ideomotor Apraxia: Evidence from Mu Suppression Type Journal Article
  Year 2016 Publication (down) Journal of Cognitive Neuroscience Abbreviated Journal J Cogn Neurosci  
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  Abstract Stroke patients with ideomotor apraxia (IMA) have difficulties controlling voluntary motor actions, as clearly seen when asked to imitate simple gestures performed by the examiner. Despite extensive research, the neurophysiological mechanisms underlying failure to imitate gestures in IMA remain controversial. The aim of the current study was to explore the relationship between imitation failure in IMA and mirror neuron system (MNS) functioning. Mirror neurons were found to play a crucial role in movement imitation and in imitation-based motor learning. Their recruitment during movement observation and execution is signaled in EEG recording by suppression of the lower (8-10 Hz) mu range. We examined the modulation of EEG in this range in stroke patients with left (n = 21) and right (n = 15) hemisphere damage during observation of video clips showing different manual movements. IMA severity was assessed by the DeRenzi's standardized diagnostic test. Results showed that failure to imitate observed manual movements correlated with diminished mu suppression in patients with damage to the right inferior parietal lobule and in patients with damage to the right inferior frontal gyrus pars opercularis-areas where major components of the human MNS are assumed to reside. Voxel-based lesion symptom mapping revealed a significant impact on imitation capacity for the left inferior and superior parietal lobules and the left post central gyrus. Both left and right hemisphere damages were associated with imitation failure typical of IMA, yet a clear demonstration of relationship to the MNS was obtained only in the right hemisphere damage group. Suppression of the 8-10 Hz range was stronger in central compared with occipital sites, pointing to a dominant implication of mu rather than alpha rhythms. However, the suppression correlated with De Renzi's apraxia test scores not only in central but also in occipital sites, suggesting a multifactorial mechanism for IMA, with a possible impact for deranged visual attention (alpha suppression) beyond the effect of MNS damage (mu suppression).  
  Address Loewenstein Hospital, Ra'anana, Israel  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  ISSN 0898-929X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26942323 Approved no  
  Call Number Serial 82  
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Author Liebermann, D.G.; Berman, S.; Weiss, P.L.T.; Levin, M.F. url  doi
openurl 
  Title Kinematics of reaching movements in a 2-d virtual environment in adults with and without stroke Type Journal Article
  Year 2012 Publication (down) IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society Abbreviated Journal IEEE Trans Neural Syst Rehabil Eng  
  Volume 20 Issue 6 Pages 778-787  
  Keywords  
  Abstract Virtual reality environments are increasingly being used for upper limb rehabilitation in poststroke patients. Our goal was to determine if arm reaching movements made in a 2-D video-capture virtual reality environment are similar to those made in a comparable physical environment. We compared arm and trunk kinematics for reaches made with the right, dominant arm to three targets (14 trials per target) in both environments by 16 adults with right poststroke hemiparesis and by eight healthy age-matched controls. Movement kinematics were recorded with a three-camera optoelectronic system at 100 samples/s. Reaching movements made by both control and stroke subjects were affected by viewing the targets in the video-capture 2-D virtual environment. Movements were slower, shorter, less straight, less accurate and involved smaller ranges of shoulder and elbow joint excursions for target reaches in the virtual environment compared to the physical environment in all subjects. Thus, there was a decrease in the overall movement quality for movements made in the 2-D virtual environment. This suggests that 2-D video-capture virtual reality environments should be used with caution when the goal of the rehabilitation program is to improve the quality of movement patterns of the upper limb.  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 1534-4320 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22907972 Approved no  
  Call Number Serial 28  
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Author Liebermann, D.G.; Biess, A.; Friedman, J.; Gielen, C.C.A.M.; Flash, T. pdf  url
doi  openurl
  Title Intrinsic joint kinematic planning. I: reassessing the Listing's law constraint in the control of three-dimensional arm movements Type Journal Article
  Year 2006 Publication (down) Experimental Brain Research Abbreviated Journal Exp Brain Res  
  Volume 171 Issue 2 Pages 139-154  
  Keywords Adolescent; Adult; Analysis of Variance; *Arm; Biomechanics; Eye Movements/*physiology; Humans; Joints/*physiology; Male; Movement/*physiology; *Musculoskeletal System; Orientation/*physiology; Posture  
  Abstract This study tested the validity of the assumption that intrinsic kinematic constraints, such as Listing's law, can account for the geometric features of three-dimensional arm movements. In principle, if the arm joints follow a Listing's constraint, the hand paths may be predicted. Four individuals performed 'extended arm', 'radial', 'frontal plane', and 'random mixed' movements to visual targets to test Listing's law assumption. Three-dimensional rotation vectors of the upper arm and forearm were calculated from three-dimensional marker data. Data fitting techniques were used to test Donders' and Listing's laws. The coefficient values obtained from fitting rotation vectors to the surfaces described by a second-order equation were analyzed. The results showed that the coefficients that represent curvature and twist of the surfaces were often not significantly different from zero, particularly not during randomly mixed and extended arm movements. These coefficients for forearm rotations were larger compared to those for the upper arm segment rotations. The mean thickness of the rotation surfaces ranged between approximately 1.7 degrees and 4.7 degrees for the rotation vectors of the upper arm segment and approximately 2.6 degrees and 7.5 degrees for those of the forearm. During frontal plane movements, forearm rotations showed large twist scores while upper arm segment rotations showed large curvatures, although the thickness of the surfaces remained low. The curvatures, but not the thicknesses of the surfaces, were larger for large versus small amplitude radial movements. In conclusion, when examining the surfaces obtained for the different movement types, the rotation vectors may lie within manifolds that are anywhere between curved or twisted manifolds. However, a two-dimensional thick surface may roughly represent a global arm constraint. Our findings suggest that Listing's law is implemented for some types of arm movement, such as pointing to targets with the extended arm and during radial reaching movements.  
  Address Department of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, 69978, Ramat Aviv, Israel. dlieberm@post.tau.ac.il  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0014-4819 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16341526 Approved no  
  Call Number Penn State @ write.to.jason @ Serial 18  
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Author Grinberg, A.; Strong, A.; Strandberg, J.; Selling, J.; Liebermann, D.G.; Bjorklund, M.; Hager, C.K. url  doi
openurl 
  Title Electrocortical activity associated with movement-related fear: a methodological exploration of a threat-conditioning paradigm involving destabilising perturbations during quiet standing Type Journal Article
  Year 2024 Publication (down) Experimental Brain Research Abbreviated Journal Exp Brain Res  
  Volume Issue Pages  
  Keywords Cnv; Eeg; Erp; Kinesiophobia; Moving platform; Re-injury anxiety  
  Abstract Musculoskeletal trauma often leads to lasting psychological impacts stemming from concerns of future injuries. Often referred to as kinesiophobia or re-injury anxiety, such concerns have been shown to hinder return to physical activity and are believed to increase the risk for secondary injuries. Screening for re-injury anxiety is currently restricted to subjective questionnaires, which are prone to self-report bias. We introduce a novel approach to objectively identify electrocortical activity associated with the threat of destabilising perturbations. We aimed to explore its feasibility among non-injured persons, with potential future implementation for screening of re-injury anxiety. Twenty-three participants stood blindfolded on a translational balance perturbation platform. Consecutive auditory stimuli were provided as low (neutral stimulus [CS(-)]) or high (conditioned stimulus [CS(+)]) tones. For the main experimental protocol (Protocol I), half of the high tones were followed by a perturbation in one of eight unpredictable directions. A separate validation protocol (Protocol II) requiring voluntary squatting without perturbations was performed with 12 participants. Event-related potentials (ERP) were computed from electroencephalography recordings and significant time-domain components were detected using an interval-wise testing procedure. High-amplitude early contingent negative variation (CNV) waves were significantly greater for CS(+) compared with CS(-) trials in all channels for Protocol I (> 521-800ms), most prominently over frontal and central midline locations (P </= 0.001). For Protocol II, shorter frontal ERP components were observed (541-609ms). Our test paradigm revealed electrocortical activation possibly associated with movement-related fear. Exploring the discriminative validity of the paradigm among individuals with and without self-reported re-injury anxiety is warranted.  
  Address Department of Community Medicine and Rehabilitation, Umea University, Umea, Sweden  
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  Language English Summary Language Original Title  
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  ISSN 0014-4819 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:38896295 Approved no  
  Call Number Serial 122  
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Author Liebermann, D.G.; Franks I.M. openurl 
  Title Video-feedback and information technologies Type Book Chapter
  Year 2008 Publication (down) Essentials of notational analysis Abbreviated Journal  
  Volume Issue Pages  
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  Address  
  Corporate Author Thesis  
  Publisher E & FN Spon Pub Place of Publication Editor I.M. Franks; M. Hughes  
  Language Summary Language Original Title  
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  Area Expedition Conference  
  Notes Approved no  
  Call Number Serial 48  
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